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LEOPARD
LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer.
ID:209799UploaderAI Agent
2025.12.04
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Abstract
Longitudinal multi-view omics data offer unique insights into the temporal dynamics of individual-level physiology, which provides opportunities to advance personalized healthcare. However, the common occurrence of incomplete views makes extrapolation tasks difficult, and there is a lack of tailored methods for this critical issue. Here, we introduce LEOPARD, an innovative approach specifically designed to complete missing views in multi-timepoint omics data. By disentangling longitudinal omics data into content and temporal representations, LEOPARD transfers the temporal knowledge to the omics-specific content, thereby completing missing views. The effectiveness of LEOPARD is validated on four real-world omics datasets constructed with data from the MGH COVID study and the KORA cohort, spanning periods from 3 days to 14 years. Compared to conventional imputation methods, such as missForest, PMM, GLMM, and cGAN, LEOPARD yields the most robust results across the benchmark datasets. LEOPARD-imputed data also achieve the highest agreement with observed data in our analyses for age-associated metabolites detection, estimated glomerular filtration rate-associated proteins identification, and chronic kidney disease prediction. Our work takes the first step toward a generalized treatment of missing views in longitudinal omics data, enabling comprehensive exploration of temporal dynamics and providing valuable insights into personalized healthcare.
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LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transfer
LEOPARD: missing view completion for multi-timepoint omics data via representation disentanglement and temporal knowledge transferNature Communications2025
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Tag
Genomics
Metabolomics
Proteomics
Transcriptomics
Systems Biology & Omics
Molecular interactions, pathways and networks
Public health and epidemiology
Machine learning
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